FORMULATION AND EVALUATION OF GASTRORETENTIVE IN SITU GELLING SYSTEM OF MITIGLINIDE
Abstract
In-situ gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange.The polymers (Na alginate and gellan gum) as primary polymers and the secondary polymer (iota carrageenan, sodium CMC) play an important role in gel strength. As the concentration of Na alginateand gellan gum increases in, the gel strength increased significantly.
Moreover, presence of CaCl2 was significant increase in gel strength,the degree of rigidness of gel increases due to increasing degree of crosslinking of divalent Ca2+ ions with the polymer chains. The CaCl2 which upon contact with 0.1N HCl (pH 1.2) the liquid polymeric solution should undergo a rapid sol-to-gel transition by means of ionic gelation. The composition of gastric fluid is rich in Cl- ions; hence on interacting with CaCl2 as cross-linking agent, in-situ gel formed rapidly.The in-situ gel formed should preserve its integrity without dissolving or eroding so as to localize the drug at absorption site for extended duration. In-vitro and buoyancy study test gave a good indication about the gastroretentive property of the selected formula (F3) in the activity of drug and it agreed with the in-vitro results and the proposed mathematical modeling for release kinetic.
References
2. Bhardwaj L., Sharma P.K., Malviya R.A., A Short Review on Gastro Retentive Formulations for Stomach Specific Drug Delivery: Special Emphasis on Floating In situ Gel Systems. African Journal of Basic & Applied Sciences 2011; 3 (6): 300-312.
3. Allen L.V., Popovich N.G., Ansel H.C., Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th Edition, Lippincott Williams & Wilkins, 2011; PP. 163.
4. European Pharmacopoeia, 8th edition, 2014, volume 1; PP.790.
5. Remington J.P., The Science and Practice of Pharmacy. 21st Edition, Lippincott Williams & Wilkins, Philadelphia, 2005; PP.745.
6. Aulton M, The Science of Dosage Form Design. 2nd Edition, Churchill Livingstone, Hungary, 2008; PP: 111 & 310.
7. Ijeoma F.U., Andreas G.S. editors. Polymers in Drug Delivery. CRC press by Tylor and Francis group, USA, 2006; PP: 35-46.
8. Hala S.Y., Yehia I.K., In situ Gelling Formulation of Naproxen for Oral Sustained Delivery System. Iraqi Journal of Pharmaceutical Sciences 2009; 18(1): 13-20.
9. Sompur C.K., Doijad R.C., Patil S.M., Maske A.P., An Approach for Development of Oral Sustained Release Suspension. International Journal of Pharma and Bio Sciences 2011; 2(2): 320-329.
10. Gandhi K.J., Deshmane S.V., Biyani K.R., Polymers in Pharmaceutical Drug Delivery System: A Review. International Journal of Pharmeutical Sciences Review & Research 2012; 14(2): 57‐ 66.
11. Keraliya R.A., Patel C.A., Patel R.C., Patel M.M., Gastro Retentive Drug Delivery System: A Novel Approach to Prolong Gastric Retention Time. Pharm Tech Medica 2013; 2(6): 396-402.
12. Prajapati V.D., Jani G.K., Khutliwala T.A., Zala B.S., Raft Forming System—An Upcoming Approach of Gastroretentive Drug Delivery system. Journal of Controlled Release 2013; 168: 151–165.
13. SankulaK.R.,Rao D.N., Formulation and Evaluation of Gastroretentive Floating Drug Delivery System of Atenolol.The Pharma Innovation Journal2014;3(5):11-18
14. Sarojini S., Manavalanb R., An Overview on Various Approaches to Gastroretentive Dosage Forms. International Journal of Drug Development & Research 2012; 4(1): 1-13.
15. Sharma N., Agarwal D., Gupta M.K., Khinchi M.P., A Comprehensive Review on Floating Drug Delivery System. International Journal of Research in Pharmaceutical and Biomedical Sciences 2011; 2(2): 428-44.
16. Patel V., Patel A., Patel H., Patel J., Patel R., Patel U., A Review on In-situ Gelling System: Novel Approach for Stomach Specific Drug Delivery. International Journal of Pharmaceutical Research and Bio- Science 2014; 3(2): 466-480.
17. ZateS.U. ,Kothawade P.I., Mahale G.H., Kapse K.P., Anantwar S.P., Gastro Retentive Bioadhesive Drug Delivery System: A Review. International Journal of PharmTech Research 2010; 2(2): 1227-1235.
18. Sravya K., Kavitha K., Rupesh K.M., Jagdeesh S.D., Gastroretentive Drug Delivery Systems: A Review. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2012; 3(3): 965-980.
19. Palla S.S., Kotha R., Paladugu A., Reddy E.R.K., Adavi1 S. L., Reddy K.R., Bilayer Floating Tablets for Gastroretentive Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology 2013; 6(3): 2097-2112.
20. Namdeo G.S., Nagesh H.A., Ajit S.K., Bhagyashree S.S., Savita H.B., Sharad N.D., Advances in Gastroretentive Drug Delivery System: An Review. International Journal of Pharmacy and Pharmaceutical Science Research 2014; 4(2): 37-48.
21. Labu Z. K., Saidul M., Islam S., Jahan M.R., Rahman M.M., Arken A.J., Sikder K., Glimpse of Comprehensive Review on Floating Drug delivery System: A Global perception. International Journal of Chemistry and pharmaceutical Sciences 2014; 2(1): 581-596.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.