FORMULATION AND CHARACTERIZATION OF BILAYER TABLET OF VILDAGLIPTIN

Maseera Sadiya Ansari; Bhupendra Tiwari; V.P. Gupta

doi:10.24092/CRPS.2024.140304

Maseera Sadiya Ansari Globus college of Pharmacy, Bhopal, M.P.
Bhupendra Tiwari Globus college of Pharmacy, Bhopal, M.P.
V.P. Gupta Globus college of Pharmacy, Bhopal, M.P.

DOI https://doi.org/10.24092/CRPS.2024.140304

Abstract

Based on different concentrations of super disintegrant nine of vildagliptin immediate-release tablets formulations were prepared. For the design of different formulations concentration of super disintegrant were taken as a variable. The dose required for the immediate release formulations were calculated by formula given by Robison and Erikson. Based on the different concentrations of polymers (HPMC K15M and Eudragit RSPO,), different bilayer sustained release matrix formulations were prepared. Concentration and types of polymers were utilized as formulation variables. For all formulations of bilayer tablets, the immediate release layer consisted up optimized formulations of vildagliptin immediate-release tablets. The formulation containing HPMC K15M and Eudragit RSPO showed higher controlled drug release. Formulation F8 showed controlled release up to 12 hrs with max release percentage.

Keywords: Super disintegrate, Bilayer tablet, sustained release, multi-layer tablets

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FORMULATION AND CHARACTERIZATION OF BILAYER TABLET OF VILDAGLIPTIN

Abstract

References

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