FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF WATER SOLUBLE DRUG BY HOT MELT TECHNIQUE
Abstract
Sustained release tablets were prepared by melt granulation method. In present investigation attempt was made to prepare sustain release Matrix Tablet formulation of Timolol hydrochloride using cetostearyl alcohol and hydroxy propyl cellulose. Physical characteristic of prepared blend and evaluation parameters are in limits Batch F5 shows better release profile. So, from that it can conclude that cetostearyl alcohol retard the release of drug in better manner for 24 hrs.
Keywords:
sustain release, timolol, dissolution, melt granulation, wax
References
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15. McGinity JW, Zhang F, Repka MA, Koleng JJ. Hot‐melt extrusion as apharmaceutical process. Am Pharm Rev. 2001; 4(2): 25‐36.
16. Breitenbach J. Melt extrusion: from process to drug delivery technology. Eur J Pharm Biopharm. 2002; 54:107‐117.
17. Crowley MM, Zhang F, Koleng JJ, McGinity JW. Stability of polyethylene oxide in matrix tablets prepared by hot‐melt extrusion, Biomaterials. 2002; 23:4241‐4248.
18. McGinity J, Hot‐melt extrusion as a pharmaceutical process. AAPS Newsmagazine. 2004; 7(3):21–25.
19. Dittgen M, Fricke S, Gerecke H, Osterwald H. Hot spin mixing: a new technology to manufacture solid dispersions, Pharmazie.1995; 50:225–226.
20. Patel PS, Mundargi RC, Ramesh Babu V, Jain D, Rangaswamy V, Aminabhavi TM. Microencapsulation of doxycyline into Poly(lactideco‐glycolide) by spray drying technique: Effect of polymer molecular weight on process parameters. J App Poly Sci. 2008; 108:4038‐4046.
2. Schafer T, Holm P, Kristensen HG. Melt granulation in a laboratoryscale high shear mixer, Drug Devl Ind Pharm. 1990; 16 (8): 1249 – 1277.
3. Heng WS, Wong TW., Melt processes for oral solid dosage forms, PharmTech.2003; 1-6.
4. Evrard B, Delattre L. In vitro evaluation of lipid matrices for the development of a sustained–release sulfamethazine bolus for lambs, Drug Devl Ind Pharm.1996; 22 (2):111-118.
5. Eliasen H, Kristensen HG, Schafer T. Growth mechanism in melt agglomeration with low viscosity binder, Int J Pharm.1999; 186: 149-159.
6. Brabander C. D., Vervaet C., Remon J. P., Development and evaluation of sustained release mini-matrices prepared by hot melt extrusion, J Control Rel. 2003; 89: 235 – 247.
7. Miyagawa Y, Okabe T, Yamaguchi Y. Controlled release of diclofenac sodium from wax matrix granules, J Pharm Sci.1996; 138: 215-224.
8. Sato H,Miyagawa Y, Okabe T. Dissolution mechanism of diclofenac sodium from wax matrix granules, J Pharm Sci.1997; 86: 929-934.
9. Breitenbach J., Melt extrusion: from process to drug delivery technology, Eur J Pharm Biopharm. 2002; 54: 107 – 117.
10. Schafer T, Mathiesen C. Melt pelletization in a high shear mixer. IX. Effect of binder particle size,Int J Pharm.1996; 139: 139-148.
11. Passerini N, Perissutti B, Monoghini M, Voinovich D, Albertini B, Cavallari C, Rodriguez L.Characterization of carbamazepine–Gelucire 50/13 microparticles prepared by a spray congealing process using ultrasounds, J Pharm Sci. 2002; 91(3): 699-707.
12. Maejima T, Osawa T, Nakjima K, Kobayashi M. Application of tumbling melt granulation method for preparing controlled release beads coated with hydrogenated castor oil, Chem Pharm Bull.1997; 45(5): 904-910.
13. Kidokoro M, Sasaki K, Haramiishi Y, Matahira N. Effect of crystallization behavior of polyethylene glycol 6000 on the properties of granule prepared by fluidized hot melt granulation (FHMG), Chem Pharm Bull. 2003; 51 (5): 487–493.
14. Kaufman HS, Falcetta JJ. Introduction to polymer science and technology: an SPE textbook, 1st ed. New Yolk: John Wiley & Son 1977;.
15. McGinity JW, Zhang F, Repka MA, Koleng JJ. Hot‐melt extrusion as apharmaceutical process. Am Pharm Rev. 2001; 4(2): 25‐36.
16. Breitenbach J. Melt extrusion: from process to drug delivery technology. Eur J Pharm Biopharm. 2002; 54:107‐117.
17. Crowley MM, Zhang F, Koleng JJ, McGinity JW. Stability of polyethylene oxide in matrix tablets prepared by hot‐melt extrusion, Biomaterials. 2002; 23:4241‐4248.
18. McGinity J, Hot‐melt extrusion as a pharmaceutical process. AAPS Newsmagazine. 2004; 7(3):21–25.
19. Dittgen M, Fricke S, Gerecke H, Osterwald H. Hot spin mixing: a new technology to manufacture solid dispersions, Pharmazie.1995; 50:225–226.
20. Patel PS, Mundargi RC, Ramesh Babu V, Jain D, Rangaswamy V, Aminabhavi TM. Microencapsulation of doxycyline into Poly(lactideco‐glycolide) by spray drying technique: Effect of polymer molecular weight on process parameters. J App Poly Sci. 2008; 108:4038‐4046.
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How to Cite
Arif Khan, Ajay Patel, Nilesh Gupta, and U. K. Jain. “FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF WATER SOLUBLE DRUG BY HOT MELT TECHNIQUE”. Current Research in Pharmaceutical Sciences, Vol. 14, no. 3, Oct. 2024, pp. 41-47, doi:10.24092/CRPS.2024.140303.
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Research Articles
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