FORMULATION AND EVALUATION OF VESICULAR DRUG DELIVERY SYSTEM OF MEFENAMIC ACID
Abstract
The objective of the present investigation was to develop niosomal based delivery system for application of mefenamic acid for treatment of inflammatory condition. The idea was to increase the bioavailability of drugs. Niosomes are known to present a solution to these side effects and the study proved that niosomes of mefenamic acid can provide improved drug bioavailability via sustained release of the drug. Among various formulations, CF7 was found to have a good release pattern and controlled release up to 24 hrs it could be suggested that the developed Pluronic P85 modified mefenamic acid niosomes could act as constant released niosomal carrier.
Keywords:
Niosomes, mefenamic acid, surfactant, sustained release, Vesicular drug delivery
References
1. Hunter CA, Dolan TF, Coombs GH, Baillie AJ. Vesicular systems (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis. Journal of pharmacy and pharmacology. 1988; 40(3):161-5.
2. Azmin MN, Florence AT, Handjania Vila RM,Stuart JFB, Vanlerberghe G, Whittaker JS. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. Journal of pharmacy and pharmacology.1985;Vol.37(4),pp237-42.
3. Malhotra M, Jain NK. Niosomes as drug carriers. Indian Drugs. 1994; Vol.31(3), pp81-6
4. Baillie AJ, Florence AT, Hume LR, Muirhead GT, Rogerson A. The preparation and properties of niosomes of non-ionic surfactant vesicles. Journal of pharmacy and pharmacology. 1985; Vol.37(12), pp863-8.
5. Azmin MN, Florence AT, HandjaniaVila RM, Stuart JFB, Vanlerberghe G, Whittaker JS. The effect of non-ionic surfactant vesicle entrapment on the absorption and distribution of methotrexate in mice. Journal of pharmacy and pharmacology. 1985; Vol.37(4), pp237-42.
6. Graham B. Interfacial phenomena in drug delivery and targeting. Switzerland: Harwood Academic Publishers; 1995.
7. Blazek-Welsh AI, Rhodes DG. Maltodextrin-based proniosomes. The AAPS Journal. 2001; Vol.3(1), pp1-8.
8. Hu C, Rhodes DG. Proniosomes: A novel drug carrier preparation. International journal of pharmaceutics. 1999; Vol.185(1), pp23-35.
9. Szoka F, Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proceedings of the National Academy of Sciences. 1978; Vol.75(9), pp4194.
10. Maver LD, Bally MB. Hope. Mj, cullis pr. Biochem Biophys Acta. 1985; Vol.8(16), pp294-302.
11. Chauhan S, Luorence MJ. The preparation of polyoxyethylene containing non- ionic surfactant vesicles. J Pharm Pharmacol. 1989; Vol.41(6), pp165-78.
12. Blazek-Welsh AI, Rhodes DG. Sem imaging predicts quality of niosomes from maltodextrin-based proniosomes. Pharmaceutical research, 2001; Vol.18(5), pp656-61.
13. Uchegbu IF, Vyas SP. Non-ionic surfactant-based vesicles (niosomes) in drug delivery. International journal of pharmaceutics. 1998; Vol.172(1), pp33-70.
14. Stafford S, Ballie AJ, Florence AT. Drug effect on the size of chemically defined nonionic surfactant vesicles. J Pharm Pharmacol 1988; (40):26-38.
15. Uchegbu IF, Florence AT. Non-ionic surfactant vesicle (niosomes): Physical and pharmaceutical chemistry. Advances in colloid and interface science. 1995; Vol.58(1), pp1-55.
16. Baillie AJ, Coombs GH, Dolan TF, Laurie J. Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate. Journal of pharmacy and pharmacology. 1986; Vol.38(7), pp502-5.
17. Yoshioka T, Sternberg B, Florence AT. Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span 20, 40, 60 and 80) and a sorbitan triester (span 85). International journal of pharmaceutics. 1994; 105(1):1-6.
18. Rogerson A, Cummings J, Florence AT. Adriamycin-loaded niosomes: Drug entrapment, stability and release. Journal of microencapsulation. 1987; Vol.4(4), pp321-8.
19. Arunothayanun P, Bernard MS, Craig DQM, Uchegbu IF, Florence AT. The effect of processing variables on the physical characteristics of non- ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether. International journal of pharmaceutics. 2000; Vol.201(1), pp7-14.
20. Carafa M, Santucci E, Lucania G. Lidocaine-loaded non-ionic surfactant vesicles: Characterization and in vitro permeation studies. International journal of pharmaceutics. 2002; Vol.231(1), pp21-32
21. Uchegbu, I.F., Florence, A.T, Nonionic surfactant vesicles; physical and pharmaceutical chemistry. Advances in colloid and interface science, 1995, 2011,58(1), 1-15
22. Saeid Moghassemi, Afra Hadjizadeh, Nano-niosmes as nanoscale drug delivery systems; An illustrated review, Journal of controlled release, 2014; Vol.18(5), pp22-36
23. Manosroi A, Wongtrakul P, Manosroi J, Sakai H, Sugawara F, Yuasa M,.
24. Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol. Colloids and Surfaces B: Biointerfaces. 2003; Vol.30(1- 2), pp129-38.
25. Balasubramaniam A, Anil Kumar V, Sadasivan Pillai K. Formulation and in-vivo evaluation of niosome-encapsulated daunorubicin hydrochloride. Drug development and industrial pharmacy. 2002; Vol.28(10), pp1181-93
26. Yoshida H, Lehr CM, Kok W, Junginger HE, Verhoef JC, Bouwstra JA. Niosomes for oral delivery of peptide drugs. Journal of controlled release. 1992; Vol.21(1-3), pp145-53.
2. Azmin MN, Florence AT, Handjania Vila RM,Stuart JFB, Vanlerberghe G, Whittaker JS. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. Journal of pharmacy and pharmacology.1985;Vol.37(4),pp237-42.
3. Malhotra M, Jain NK. Niosomes as drug carriers. Indian Drugs. 1994; Vol.31(3), pp81-6
4. Baillie AJ, Florence AT, Hume LR, Muirhead GT, Rogerson A. The preparation and properties of niosomes of non-ionic surfactant vesicles. Journal of pharmacy and pharmacology. 1985; Vol.37(12), pp863-8.
5. Azmin MN, Florence AT, HandjaniaVila RM, Stuart JFB, Vanlerberghe G, Whittaker JS. The effect of non-ionic surfactant vesicle entrapment on the absorption and distribution of methotrexate in mice. Journal of pharmacy and pharmacology. 1985; Vol.37(4), pp237-42.
6. Graham B. Interfacial phenomena in drug delivery and targeting. Switzerland: Harwood Academic Publishers; 1995.
7. Blazek-Welsh AI, Rhodes DG. Maltodextrin-based proniosomes. The AAPS Journal. 2001; Vol.3(1), pp1-8.
8. Hu C, Rhodes DG. Proniosomes: A novel drug carrier preparation. International journal of pharmaceutics. 1999; Vol.185(1), pp23-35.
9. Szoka F, Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proceedings of the National Academy of Sciences. 1978; Vol.75(9), pp4194.
10. Maver LD, Bally MB. Hope. Mj, cullis pr. Biochem Biophys Acta. 1985; Vol.8(16), pp294-302.
11. Chauhan S, Luorence MJ. The preparation of polyoxyethylene containing non- ionic surfactant vesicles. J Pharm Pharmacol. 1989; Vol.41(6), pp165-78.
12. Blazek-Welsh AI, Rhodes DG. Sem imaging predicts quality of niosomes from maltodextrin-based proniosomes. Pharmaceutical research, 2001; Vol.18(5), pp656-61.
13. Uchegbu IF, Vyas SP. Non-ionic surfactant-based vesicles (niosomes) in drug delivery. International journal of pharmaceutics. 1998; Vol.172(1), pp33-70.
14. Stafford S, Ballie AJ, Florence AT. Drug effect on the size of chemically defined nonionic surfactant vesicles. J Pharm Pharmacol 1988; (40):26-38.
15. Uchegbu IF, Florence AT. Non-ionic surfactant vesicle (niosomes): Physical and pharmaceutical chemistry. Advances in colloid and interface science. 1995; Vol.58(1), pp1-55.
16. Baillie AJ, Coombs GH, Dolan TF, Laurie J. Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate. Journal of pharmacy and pharmacology. 1986; Vol.38(7), pp502-5.
17. Yoshioka T, Sternberg B, Florence AT. Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span 20, 40, 60 and 80) and a sorbitan triester (span 85). International journal of pharmaceutics. 1994; 105(1):1-6.
18. Rogerson A, Cummings J, Florence AT. Adriamycin-loaded niosomes: Drug entrapment, stability and release. Journal of microencapsulation. 1987; Vol.4(4), pp321-8.
19. Arunothayanun P, Bernard MS, Craig DQM, Uchegbu IF, Florence AT. The effect of processing variables on the physical characteristics of non- ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether. International journal of pharmaceutics. 2000; Vol.201(1), pp7-14.
20. Carafa M, Santucci E, Lucania G. Lidocaine-loaded non-ionic surfactant vesicles: Characterization and in vitro permeation studies. International journal of pharmaceutics. 2002; Vol.231(1), pp21-32
21. Uchegbu, I.F., Florence, A.T, Nonionic surfactant vesicles; physical and pharmaceutical chemistry. Advances in colloid and interface science, 1995, 2011,58(1), 1-15
22. Saeid Moghassemi, Afra Hadjizadeh, Nano-niosmes as nanoscale drug delivery systems; An illustrated review, Journal of controlled release, 2014; Vol.18(5), pp22-36
23. Manosroi A, Wongtrakul P, Manosroi J, Sakai H, Sugawara F, Yuasa M,.
24. Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol. Colloids and Surfaces B: Biointerfaces. 2003; Vol.30(1- 2), pp129-38.
25. Balasubramaniam A, Anil Kumar V, Sadasivan Pillai K. Formulation and in-vivo evaluation of niosome-encapsulated daunorubicin hydrochloride. Drug development and industrial pharmacy. 2002; Vol.28(10), pp1181-93
26. Yoshida H, Lehr CM, Kok W, Junginger HE, Verhoef JC, Bouwstra JA. Niosomes for oral delivery of peptide drugs. Journal of controlled release. 1992; Vol.21(1-3), pp145-53.
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How to Cite
Deepak Kumar, Nilesh Gupta, Ajay Patel, and U. K. Jain. “FORMULATION AND EVALUATION OF VESICULAR DRUG DELIVERY SYSTEM OF MEFENAMIC ACID”. Current Research in Pharmaceutical Sciences, Vol. 14, no. 3, Oct. 2024, pp. 28-35, doi:10.24092/CRPS.2024.140301.
Section
Research Articles
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