A Concise Review on Spansules: A New Method of Drug Delivery

Abhilasha Bhadoriya; Trupti Shukla

doi:10.24092/CRPS.2023.130102

Abhilasha Bhadoriya Institute of Pharmacy, SAGE University, Indore, India 452020
Trupti Shukla Institute of Pharmacy, SAGE University, Indore, India 452020

DOI https://doi.org/10.24092/CRPS.2023.130102

Abstract

Spansules are considered as an Advanced Drug Delivery System because they allow for controlled and sustained release of medication over an extended period of time. This type of delivery system can provide a constant plasma drug concentration over a wide range of time, which can improve treatment outcomes and reduce the risk of side effects. In addition to providing sustained release, Spansules can also be used to deliver multiple drugs in a single dosage form. The multi-drug regimen capability of Spansules is also beneficial, as it allows for the delivery of multiple drugs in a single dosage form. This can improve patient compliance with their medication regimen, simplify dosing, and reduce the risk of drug interactions. This can be particularly useful in cases where a patient requires treatment with multiple medications to manage a complex medical condition. Spansules can act as biphasic release drug delivery system that can be used to provide both immediate and sustained release of medication. These systems can be useful in cases where a patient requires rapid relief of symptoms followed by ongoing management over a longer period of time. Overall, Spansules are a versatile and effective drug delivery system that can provide several benefits to patients and healthcare providers.

Keywords: Spansules, Biphasic, Controlled release, Sustained release, Drug

References

1. Maurya R, Sharma PK, Malviya R. A review on controlled drug release formulation: spansules. International Journal of Pharma Sciences and Research. 2014; 5(03): 78-81.
2. Biswal B, Karna N, Bhavsar B. Formulation and Evaluation of Repaglinide Buccal Tablet: Ex Vivo Bioadhesion Study and Ex Vivo Permeability Study. J App Pharm Sci. 2014; 4 (05): 096-103.
3. Parashar AK. Synthesis and characterization of temozolomide loaded theranostic quantum dots for the treatment of brain glioma. J Med Pharm Allied Sci [Internet]. 2021;10(3):2778–82.
4. Jeong K, Kang CS, Kim Y, Lee Y-D, Kwon IC, Kim S. Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy. Cancer Lett [Internet]. 2016;374(1):31–43.
5. Klinjapo R, Krasaekoopt W. Microencapsulation of color and flavor in confectionery products. In: Natural and Artificial Flavoring Agents and Food Dyes. Elsevier. 2018:457–94.
6. Zhang Y, Xu C, Gu ZQ. China. In: Bioequivalence Requirements in Various Global Jurisdictions. Cham: Springer International Publishing; 2017: 59–74.
7. Niknam E, Naffakh-Moosavy H, Moosavifard SE, Ghahraman Afshar M. Amorphous V-doped Co3S4 yolk-shell hollow spheres derived from metal-organic framework for high-performance asymmetric supercapacitors. J Alloys Compd [Internet]. 2022;895(162720):162720.
8. Friend DR, Pangburn S. Site-specific drug delivery. Med Res Rev [Internet]. 1987;7(1):53–106.
9. Sintzel MB, Merkli A, Tabatabay C, Gurny R. Influence of irradiation sterilization on polymers used as drug carriers—A review. Drug Dev Ind Pharm [Internet]. 1997;23(9):857–78.
10. Parashar AK. Synthesis and characterization of ligand anchored poly propyleneiminedendrimers for the treatment of brain glioma. J Med Pharm Allied Sci [Internet]. 2021;10(3):2784–9.