Hepatoprotective Activity of Ficus religiosa Leaf Extract in Rats
Abstract
Ficus religiosa was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. IV administration of a sub-lethal dose of paracetamol (500 mg/kg) produced liver damage in rats as manifested by the rise in serum level of transaminases (AST and ALT). Ttreatment of rats with Ficus religiosa(200 mg/kg) prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml/kg; orally) also raised the serum AST and ALT levels. The same dose of Ficus religiosa(200 mg/kg) was able to prevent the CCl4-induced rise in serum enzymes. These results indicate that Ficus religiosa possesses hepatoprotective activity.
Keywords:
Ficus religiosa, paracetamol, CCl4, Hepatoprotective.
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2. Kirthikar KR, Basu BD. Indian medicinal plants. Vol. 3, 2nd ed, India: International Book Distributors, 1996. p. 2329-2331.
3. Nadkarni KM, Nadkarni AK. Indian material medica. Vol. 1, India: Popular Prakashan, 1995. p. 545- 547.
4. Seong-Kuk K, Dong-Ok C, Hee-Jong C. Purification and identification of antimicrobial substances in phenolic fraction of fig leaves. Han'guk Nonghwa Hakhoechi 1995; 38: 293-296.
5. Jeong WS, Lachance PA. Phytosterols and fatty acids in fig (Ficus carica, var. Mission) fruit and tree components. J Food Sci 2001; 66: 278-281.
6. Weiping Y, Hongming C, Tianxin W, Mengshen C. A new coumarin compound with anticancer activity. Zhongcaoyao 1997; 28: 3-4.
7. Shai R, Yoel K, Ruth R, Michael S, Raphael M. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: Isolation and structure elucidation. J Nat Prod 2001; 64: 993-996.
8. Saeed MA, Sabir AW. Irritant potential of triterpenoids from Ficus carica leaves. Fitoterapia 2002; 73: 417-420.
9. Subhash CM, Tapan KM, Das J, Pal M, Saha BP. Hepatoprotective activity of Ficus racemosa leaf extract on liver damage caused by carbon tetrachloride in rats. Phytother Res 1999; 13: 430-432.
10. Subhash CM, Saraswathi B, Ashok Kumar CK, Mohana Lakshmi S, Maiti BC. Protective effect of leaf extract of Ficus hispida Linn against paracetamol-induced hepatotoxicity in rats. Phytother Res 2000; 14: 457-459.
11. Bhattacharjee SK Handbook of Medicinal Plants. Pointer Publishers, Jaipur, India.
12. Brown VK, Robinson V & Stevenson DE (1963) A note on the toxicity and solvent editions, properties of dimethylsulphoxide. Journal of Pharmaceutical Pharmacology 15: 688-692
13. Chopra RN, Chopra IC, Handa KL & Kapin LD. Indigenous Drugs of India. U.N. Dhur and Sons Private Ltd., Calcutta, India.
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How to Cite
Selvan, A., and V. Chourasia. “Hepatoprotective Activity of Ficus Religiosa Leaf Extract in Rats”. Current Research in Pharmaceutical Sciences, Vol. 7, no. 2, July 2017, pp. 64-68, doi:10.24092/CRPS.2017.070205.
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