A Review on Therapeutic Potentials of Crocetin-A Carotenoid Derived from Saffron

  • Priya Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (M. I.E. T.) NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India
  • Shobhit kumar Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (M. I.E. T.) NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India
  • S K Gupta Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (M. I.E. T.) NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India


Natural dyes recognized as carotenoids have found application in health care system due to  their wide biological activities, high safety margins and lower cost. Crocetin, a carotenoid  constituent of saffron has shown wide range of pharmacological applications due to its  significant antioxidant properties. It is used as antifungal, antimicrobial and antiallergic agent.  Crocetin has shown significant potential as an anti- tumor agent in animal models and cell  culture systems.

Current review has shown crocetin’s multispectrum pharmacological benefits for the treatment  of various chronic diseases such as cancer, diabetes, parkinson’s and alzheimer’s disease. This  review focus on various studies done on crocetin explaining its broa d spectrum  pharmacological activities. In addition, this review will also focus on the pharmacokinetic  studies of crocetin on human and animals. Crocetin is a highly potent molecule because of its  strong antioxidant properties. In the near future, increasing its bioavailability using novel drug  delivery methods having minimum side effects will get this promising natural molecule to the  forefront of therapy for the treatment of various chronic human diseases like cancer, diabetes,  parkinson’s and alzheimer’s disease.

Keywords: Carotenoid, Antioxidant, Anticancer, Anti-alzheimer, Antidiabetic, Crocetin


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How to Cite
Priya, Shobhit kumar, and S K Gupta. “A Review on Therapeutic Potentials of Crocetin-A Carotenoid Derived from Saffron”. Current Research in Pharmaceutical Sciences, Vol. 9, no. 4, Jan. 2020, pp. 54-62, doi:10.24092/CRPS.2019.090401.
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