https://www.crpsonline.com/index.php/crps <p>Current Research in Pharmaceutical Sciences, a Multidisciplinary Pharmacy Journal is an Online,Quaterly published, Peer Reviewed International Journal and publishes from Empro, India. Our website, crpsonline.com is web-based center for pharmaceutical information. CRPS publishes manuscripts (original research, review articles, mini reviews, short communication and case study) on original work either experimental or theoretical</p> Empro Professional Scientific Association (EPSA) en-US Current Research in Pharmaceutical Sciences 2250-2688 https://www.crpsonline.com/index.php/crps/article/view/388 <p>Drug delivery to the brain remains the biggest hurdle in central nervous system (CNS) disorders due to the protective nature of the blood-brain barrier (BBB) obstructs most of the drugs from reaching their target site. Intranasal drug delivery has gained attention as a non-invasive and direct nose-to-brain targeting to bypass the BBB. However, conventional nasal formulations often struggle with rapid clearance and poor absorption. This review article focuses on nanospanlastics, a highly flexible, surfactant-based nanovesicle, as a novel and promising approach for nose-to-brain drug delivery. In this review article, we will discuss methods of nanospanlastics formulation, their mechanism of drug release, ability to carry a wide range of drugs, protect them from degradation, and release them in a controlled manner, making them useful for treating chronic CNS disorders. The review also covers recent research showing their potential in managing various chronic CNS disorders like Alzheimer’s, Parkinson’s, epilepsy, brain tumors, and more. Growing interest and encouraging preclinical results show that nanospanlastics offer a powerful new tool in the fight against neurological and psychiatric disorders. Looking ahead, further clinical studies and scalable production methods will be significant to bringing this innovative technology from the lab to the clinic.</p> Priyanka Singh Poonam Maurya Raj Keshwar Prasad Copyright (c) 2025 Priyanka Singh, Poonam Maurya, Raj Keshwar Prasad http://creativecommons.org/licenses/by-nc/4.0 2025-10-08 2025-10-08 75 82 10.24092/CRPS.2025.150301 https://www.crpsonline.com/index.php/crps/article/view/389 <p>Microbes have a substantial role in the spread of dangerous infections, and how they spread to humans presents an increasing challenge to public health. The effective management of these types of infections and the mitigation of antimicrobial resistance can be accomplished using novel pharmaceuticals, which are essential to ongoing research within the scientific community. The strategic use of current antimicrobial alternatives alongside novel drug regimens warrants investigation to address the significant issue of drug resistance. Extended research in antimicrobial drugs has shown that, among various targets, targeting proteins is the most effective approach for developing robust treatments. Despite considerable progress in antibiotic therapies and the availability of various inhibitors for drug-resistant bacterial strains, there remains a critical necessity to develop new compounds that possess a favourable safety profile to tackle this issue. In immunocompromised individuals, severe diseases resulting from pathogenic fungi are frequently observed. Fungal infections are common, yet treatment options remain limited; thus, the development of new antifungal agents is crucial for community members.</p> Chander Shekhar Sharma Mukesh Kumar Gupta Shikha Sharma Copyright (c) 2025 Chander Shekhar Sharma, Mukesh Kumar Gupta, Shikha Sharma http://creativecommons.org/licenses/by-nc/4.0 2025-10-08 2025-10-08 83 104 10.24092/CRPS.2025.150302